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Tall Stature with Bumpy Tongue: A Rare Polyendocrine Neoplasia Syndrome
How to cite this article: Yadav J, Gupta S, Sodhi K. Tall stature with bumpy tongue: A rare polyendocrine neoplasia syndrome. J Pediatr Endocrinol Diabetes 2021;1:30-1.
A 15-year-old girl presented with multiple nodular swellings over the tongue, lips, angle of the mouth, and bilateral upper eyelids. She was comparatively tall (height 160 cm, +0.6 Z) when compared to her mid-parental height (146 cm, −2.12 Z) and had a marfanoid habitus with bilateral ectropion on examination [Figure 1]. Due to the clinical phenotype and suspicion of the polyendocrine syndrome, investigations for medullary carcinoma thyroid (MTC) were done which showed high serum calcitonin 956 pg/mL (normal range < 10 pg/mL). Ultrasound thyroid revealed two intrathyroidal lesions with calcification [Figure 2] and biopsy of the lesion confirmed the diagnosis of MTC. The clinical features and lab abnormalities established the diagnosis of multiple endocrine neoplasia type 2B (MEN2B). MEN2B is a polyendocrine syndrome caused by activating mutations in the RET proto-oncogene and is characterized by MTC (100% cases), pheochromocytoma (50%), and a classic clinical phenotype which includes the presence of mucosal neuromas on the lips, tongue, or conjunctiva, marfanoid habitus, pes cavus, pectus excavatum, high-arched palate, scoliosis, slipped capital femoral epiphysis, joint laxity, proximal muscle weakness, and thickened lips. Alacrima, ectropion, and ptosis can also be seen. Surgical treatment for thyroid and adrenal lesions offers the best chances of survival.
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